Diet has independent effects on the pace and shape of aging in Drosophila melanogaster.

ABSTRACT: Studies examining how diet affects mortality risk over age typically characterise mortality using parameters such as aging rates, which condense how much and how quickly the risk of dying changes over time into a single measure. Demographers have suggested that decoupling the tempo and the magnitude of changing mortality risk may facilitate comparative analyses of mortality trajectories, but it is unclear what biologically meaningful information this approach offers. Here, we determine how the amount and ratio of protein and carbohydrate ingested by female Drosophila melanogaster affects how much mortality risk increases over a time-standardised life-course (the shape of aging) and the tempo at which animals live and die (the pace of aging). We find that pace values increased as flies cons

SUBMITTER: Ruth Archer C 

PROVIDER: S-EPMC5765211 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature