Family history of cancer in children and adolescents with germ cell tumours: a report from the Children's Oncology Group.

ABSTRACT:

Background

Studies of family history of cancer in paediatric germ cell tumours (GCTs) are few, and none has had sufficient sample size to specifically evaluate family history of GCT.

Methods

We utilised family history data from a paediatric GCT study to calculate standardised incidence ratios (SIR) for GCT and other cancers using age- and sex-specific incidence rates from the SEER Program.

Results

This analysis included 7998 relatives of paediatric GCT probands. We observed a higher number of GCT cases than expected in male and female relatives of probands (SIR=2.38, 95% CI 1.25, 3.51 for males; SIR=14.3, 95% CI 0.29, 28.4 for females). Further, we observed a particularly strong SIR for relatives of probands with intracranial GCT (SIR=8.07, 95% CI 3.51, 12.6). The SIR

SUBMITTER: Poynter JN 

PROVIDER: S-EPMC5765220 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature