PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer.

ABSTRACT: Despite multidisciplinary treatment for patients with advanced gastric cancer, their prognosis remains poor. Therefore, the development of novel therapeutic strategies is urgently needed, and immunotherapy utilizing anti-programmed death 1/-programmed death ligand-1 mAb is an attractive approach. However, as there is limited information on how programmed death ligand-1 is upregulated on tumor cells within the tumor microenvironment, we examined the mechanism of programmed death ligand-1 regulation with a particular focus on interferon gamma in an in vitro setting and in clinical samples. Our in vitro findings showed that interferon gamma upregulated programmed death ligand-1 expression on solid tumor cells through the JAK-signal transducer and activator of transcription pathway, and impair

SUBMITTER: Mimura K 

PROVIDER: S-EPMC5765310 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature