Standardised evaluation of medicine acceptability in paediatric population: reliability of a model.

ABSTRACT:

Objectives

Our novel tool to standardise the evaluation of medicine acceptability was developed using observational data on medicines use measured in a paediatric population included for this purpose (0-14 years). Using this tool, any medicine may be positioned on a map and assigned to an acceptability profile. The present exploration aimed to verify its statistical reliability.

Methods

Permutation test has been used to verify the significance of the relationships among measures highlighted by the acceptability map. Bootstrapping has been used to demonstrate the accuracy of the model (map, profiles and scores of acceptability) regardless of variations in the data. Lastly, simulations of enlarged data sets (×2; ×5; ×10) have been built to study the model's consistency.

Key

SUBMITTER: Vallet T 

PROVIDER: S-EPMC5765461 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature