Application of Bayesian analysis to the doubly labelled water method for total energy expenditure in humans.

ABSTRACT:

Rationale

The doubly labelled water (DLW) method is the reference method for the estimation of free-living total energy expenditure (TEE). In this method, where both ² H and ¹⁸ O are employed, different approaches have been adopted to deal with the non-conformity observed regarding the distribution space for the labels being non-coincident with total body water. However, the method adopted can have a significant effect on the estimated TEE.

Methods

We proposed a Bayesian reasoning approach to modify an assumed prior distribution for the space ratio using experimental data to derive the TEE. A Bayesian hierarchical approach was also investigated. The dataset was obtained from 59 adults (37 women) who underwent a DLW experiment during which the ²

SUBMITTER: Ruan Y 

PROVIDER: S-EPMC5765481 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature