Global analysis of gene expression profiles in the submandibular salivary gland of klotho knockout mice.

ABSTRACT: Salivary dysfunction commonly occurs in many older adults and is considered a physiological phenomenon. However, the genetic changes in salivary glands during aging have not been characterized. The present study analyzed the gene expression profile in salivary glands from accelerated aging klotho deficient mice (klotho-/-, 4 weeks old). Microarray analysis showed that 195 genes were differentially expressed (z-score > 2 in two independent arrays) in klotho null mice compared to wild-type mice. Importantly, alpha2-Na⁺ /K⁺ -ATPase (Atp1a2), Ca²⁺ -ATPase (Atp2a1), epidermal growth factor (EGF), and nerve growth factor (NGF), which have been suggested to be regulators of submandibular salivary gland function, were significantly decreased. When a network was con

SUBMITTER: Kwon SM 

PROVIDER: S-EPMC5765504 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature