Impact of maternal vaccination timing and influenza virus circulation on birth outcomes in rural Nepal.

ABSTRACT:

Objective

To describe the effect of maternal vaccination on birth outcomes in rural Nepal, modified by timing of vaccination in pregnancy and influenza virus activity.

Methods

A secondary analysis was conducted using data from two annual cohorts of a randomized controlled trial. A total of 3693 pregnant women from Sarlahi District were enrolled between April 25, 2011, and September 9, 2013. All participants were aged 15-40 years and received a trivalent inactivated influenza vaccine or placebo. The outcome measures included birth weight, pregnancy length, low birth weight (<2500 g), preterm birth, and small-for-gestational-age birth.

Results

Data were available on birth weight for 2741 births and on pregnancy length for 3623 births. Maternal vaccination increased mean

SUBMITTER: Kozuki N 

PROVIDER: S-EPMC5765513 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature