CirclncRNAnet: an integrated web-based resource for mapping functional networks of long or circular forms of noncoding RNAs.

ABSTRACT:

Background

Despite their lack of protein-coding potential, long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) have emerged as key determinants in gene regulation, acting to fine-tune transcriptional and signaling output. These noncoding RNA transcripts are known to affect expression of messenger RNAs (mRNAs) via epigenetic and post-transcriptional regulation. Given their widespread target spectrum, as well as extensive modes of action, a complete understanding of their biological relevance will depend on integrative analyses of systems data at various levels.

Findings

While a handful of publicly available databases have been reported, existing tools do not fully capture, from a network perspective, the functional implications of lncRNAs or circRNAs of interest. Throu

SUBMITTER: Wu SM 

PROVIDER: S-EPMC5765557 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature