Genetic diversity of three surface protein genes in Plasmodium malariae from three Asian countries.

ABSTRACT:

Background

Genetic diversity of the three important antigenic proteins, namely thrombospondin-related anonymous protein (TRAP), apical membrane antigen 1 (AMA1), and 6-cysteine protein (P48/45), all of which are found in various developmental stages of Plasmodium parasites is crucial for targeted vaccine development. While studies related to the genetic diversity of these proteins are available for Plasmodium falciparum and Plasmodium vivax, barely enough information exists regarding Plasmodium malariae. The present study aims to demonstrate the genetic variations existing among these three genes in P. malariae by analysing their diversity at nucleotide and protein levels.

Methods

Three surface protein genes were isolated from 45 samples collected in Thailand (N = 33), Myanm

SUBMITTER: Srisutham S 

PROVIDER: S-EPMC5765603 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature