Preventive effects of Salvia officinalis leaf extract on insulin resistance and inflammation in a model of high fat diet-induced obesity in mice that responds to rosiglitazone.

ABSTRACT:

Background

Salvia officinalis (sage) is a native plant to the Mediterranean region and has been used for a long time in traditional medicine for various diseases. We investigated possible anti-diabetic, anti-inflammatory and anti-obesity effects of sage methanol (MetOH) extract in a nutritional mouse model of obesity, inflammation and insulin resistance, as well as its effects on lipolysis and lipogenesis in 3T3-L1 cells.

Methods

Diet-induced obese (DIO) mice were treated for five weeks with sage methanol extract (100 and 400 mg kg^-1/day bid), or rosiglitazone (3 mg kg^-1/day bid), as a positive control. Energy expenditure, food intake, body weight, fat mass, liver glycogen and lipid content were evaluated. Blood glucose, and plasma levels of insu

SUBMITTER: Ben Khedher MR 

PROVIDER: S-EPMC5765810 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature