HIV-1 and hepatitis C virus selection bottleneck in Chinese people who inject drugs.

ABSTRACT:

Objectives

For both HIV-1 and hepatitis C virus (HCV), assessing the stringency of the transmission process is a scientific priority. Enumerations of transmitted/founder (TF) viruses have shown a strict transmission bottleneck in sexual transmission of HIV-1 and a wide range in the multiplicity of infection in HCV. Here, we aim to determine the stringency of parenteral transmission for HIV-1 and HCV in people who inject drugs (PWID).

Design

We used molecular sequencing and several complementary analyses to enumerate the TF HIV-1 and HCV variants in a well described cohort of PWID in Xinjiang, China.

Methods

We performed single genome sequencing of HIV-1 env and 5' half HCV genomes, then applied phylogenetic analysis and validated models of early virus diversification

SUBMITTER: Li F 

PROVIDER: S-EPMC5765877 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature