Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children.

ABSTRACT: Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [N_TOTAL=679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele in

SUBMITTER: Schnurr TM 

PROVIDER: S-EPMC5765967 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature