Biodegradable Viral Nanoparticle/Polymer Implants Prepared via Melt-Processing.

ABSTRACT: Viral nanoparticles have been utilized as a platform for vaccine development and are a versatile system for the display of antigenic epitopes for a variety of disease states. However, the induction of a clinically relevant immune response often requires multiple injections over an extended period of time, limiting patient compliance. Polymeric systems to deliver proteinaceous materials have been extensively researched to provide sustained release, which would limit administration to a single dose. Melt-processing is an emerging manufacturing method that has been utilized to create polymeric materials laden with proteins as an alternative to typical solvent-based production methods. Melt-processing is advantageous because it is continuous, solvent-free, and 100% of the therapeutic protein i

SUBMITTER: Lee PW 

PROVIDER: S-EPMC5765982 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature