Mapping the order and pattern of brain structural MRI changes using change-point analysis in premanifest Huntington's disease.

ABSTRACT: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that progressively affects motor, cognitive, and emotional functions. Structural MRI studies have demonstrated brain atrophy beginning many years prior to clinical onset ("premanifest" period), but the order and pattern of brain structural changes have not been fully characterized. In this study, we investigated brain regional volumes and diffusion tensor imaging (DTI) measurements in premanifest HD, and we aim to determine (1) the extent of MRI changes in a large number of structures across the brain by atlas-based analysis, and (2) the initiation points of structural MRI changes in these brain regions. We adopted a novel multivariate linear regression model to detect the inflection points at which the MRI chang

SUBMITTER: Wu D 

PROVIDER: S-EPMC5766002 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature