Obesity and abnormal glucose tolerance in offspring of diabetic mothers: A systematic review and meta-analysis.

ABSTRACT:

Background

Rising prevalence of childhood obesity and type 2 diabetes mellitus (T2DM) is an emerging public health issue.

Objectives

To investigate the association of maternal hyperglycemia exposure during pregnancy with obesity and abnormal glucose tolerance in offspring, and the age at occurrence.

Methods

We searched MEDLINE and EMBASE for observational studies on obesity and diabetes in offspring of diabetic mothers (gestational diabetes mellitus (GDM), type 1 diabetes mellitus (T1DM) and T2DM), and those on non-diabetic mothers. We performed fixed effect meta-analysis for all studies except when heterogeneity was detected. The quality of studies was evaluated using the Risk of Bias Assessment Tool for Nonrandomized Studies (RoBANS).

Results

Twenty observati

SUBMITTER: Kawasaki M 

PROVIDER: S-EPMC5766126 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature