Classification of patients with knee osteoarthritis in clinical phenotypes: Data from the osteoarthritis initiative.

ABSTRACT:

Objectives

The existence of phenotypes has been hypothesized to explain the large heterogeneity characterizing the knee osteoarthritis. In a previous systematic review of the literature, six main phenotypes were identified: Minimal Joint Disease (MJD), Malaligned Biomechanical (MB), Chronic Pain (CP), Inflammatory (I), Metabolic Syndrome (MS) and Bone and Cartilage Metabolism (BCM). The purpose of this study was to classify a sample of individuals with knee osteoarthritis (KOA) into pre-defined groups characterized by specific variables that can be linked to different disease mechanisms, and compare these phenotypes for demographic and health outcomes.

Methods

599 patients were selected from the OAI database FNIH at 24 months' time to conduct the study. For each phenotype, c

SUBMITTER: Dell'Isola A 

PROVIDER: S-EPMC5766143 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature