Evaluation of bloodstream infections, Clostridium difficile infections, and gut microbiota in pediatric oncology patients.

ABSTRACT: Bloodstream infections (BSI) and Clostridium difficile infections (CDI) in pediatric oncology/hematology/bone marrow transplant (BMT) populations are associated with significant morbidity and mortality. The objective of this study was to explore possible associations between altered microbiome composition and the occurrence of BSI and CDI in a cohort of pediatric oncology patients. Stool samples were collected from all patients admitted to the pediatric oncology floor from Oct.-Dec. 2012. Bacterial profiles from patient stools were determined by bacterial 16S rRNA gene profiling. Differences in overall microbiome composition were assessed by a permutation-based multivariate analysis of variance test, while differences in the relative abundances of specific taxa were assessed by Kruskal-Wal

SUBMITTER: Nycz BT 

PROVIDER: S-EPMC5766145 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature