Modeling the effect of boost timing in murine irradiated sporozoite prime-boost vaccines.

ABSTRACT: Vaccination with radiation-attenuated sporozoites has been shown to induce CD8+ T cell-mediated protection against pre-erythrocytic stages of malaria. Empirical evidence suggests that successive inoculations often improve the efficacy of this type of vaccines. An initial dose (prime) triggers a specific cellular response, and subsequent inoculations (boost) amplify this response to create a robust CD8+ T cell memory. In this work we propose a model to analyze the effect of T cell dynamics on the performance of prime-boost vaccines. This model suggests that boost doses and timings should be selected according to the T cell response elicited by priming. Specifically, boosting during late stages of clonal contraction would maximize T cell memory production for vaccines using lower doses of ir

SUBMITTER: Fernandez-Arias C 

PROVIDER: S-EPMC5766151 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature