A systematic atlas of chaperome deregulation topologies across the human cancer landscape.

ABSTRACT: Proteome balance is safeguarded by the proteostasis network (PN), an intricately regulated network of conserved processes that evolved to maintain native function of the diverse ensemble of protein species, ensuring cellular and organismal health. Proteostasis imbalances and collapse are implicated in a spectrum of human diseases, from neurodegeneration to cancer. The characteristics of PN disease alterations however have not been assessed in a systematic way. Since the chaperome is among the central components of the PN, we focused on the chaperome in our study by utilizing a curated functional ontology of the human chaperome that we connect in a high-confidence physical protein-protein interaction network. Challenged by the lack of a systems-level understanding of proteostasis alteration

SUBMITTER: Hadizadeh Esfahani A 

PROVIDER: S-EPMC5766242 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature