Salivary proteomics of healthy dogs: An in depth catalog.

ABSTRACT:

Objective

To provide an in-depth catalog of the salivary proteome and endogenous peptidome of healthy dogs, evaluate proteins and peptides with antimicrobial properties, and compare the most common salivary proteins and peptides between different breed phylogeny groups.

Methods

36 healthy dogs without evidence of periodontal disease representing four breed phylogeny groups, based upon single nucleotide polymorphism haplotypes (ancient, herding/sighthound, and two miscellaneous groups). Saliva collected from dogs was pooled by phylogeny group and analyzed using nanoscale liquid chromatography-tandem mass spectrometry. Resulting tandem mass spectra were compared to databases for identification of endogenous peptides and inferred proteins.

Results

2,491 proteins and endo

SUBMITTER: Torres SMF 

PROVIDER: S-EPMC5766244 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature