Induction of protein citrullination and auto-antibodies production in murine exposed to nickel nanomaterials.

ABSTRACT: Citrullination, or the post-translational deimination of polypeptide-bound arginine, is involved in several pathological processes in the body, including autoimmunity and tumorigenesis. Recent studies have shown that nanomaterials can trigger protein citrullination, which might constitute a common pathogenic link to disease development. Here we demonstrated auto-antibody production in serum of nanomaterials-treated mice. Citrullination-associated phenomena and PAD levels were found to be elevated in nanomaterials -treated cell lines as well as in the spleen, kidneys and lymph nodes of mice, suggesting a systemic response to nanomaterials injection, and validated in human pleural and pericardial malignant mesothelioma (MM) samples. The observed systemic responses in mice exposed to nanomate

SUBMITTER: Mohamed BM 

PROVIDER: S-EPMC5766588 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature