Plasma Lipidomic Signature of Rectal Adenocarcinoma Reveals Potential Biomarkers.

ABSTRACT:

Background

Rectal adenocarcinoma (RAC) is a common malignant tumor of the digestive tract and survival is highly dependent upon stage of disease at diagnosis. Lipidomic strategy can be used to identify potential biomarkers for establishing early diagnosis or therapeutic programs for RAC.

Objective

To evaluate the lipoperoxidation biomarkers and lipidomic signature in the plasma of patients with RAC (n = 23) and healthy controls (n = 18).

Methods

Lipoperoxidation was evaluated based on malondialdehyde (MDA) and F₂-isoprostane levels and the lipidomic profile obtained by gas chromatography and high resolution mass spectrometry (ESI-q-TOF) associated with a multivariate statistical technique.

Results

The most abundant ions identified in th

SUBMITTER: Fernandes Messias MC 

PROVIDER: S-EPMC5766651 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature