Ontology highlight
ABSTRACT:
SUBMITTER: Yui S
PROVIDER: S-EPMC5766831 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Cell stem cell 20171214 1
Tissue regeneration requires dynamic cellular adaptation to the wound environment. It is currently unclear how this is orchestrated at the cellular level and how cell fate is affected by severe tissue damage. Here we dissect cell fate transitions during colonic regeneration in a mouse dextran sulfate sodium (DSS) colitis model, and we demonstrate that the epithelium is transiently reprogrammed into a primitive state. This is characterized by de novo expression of fetal markers as well as suppres ...[more]