Cerebral hypoperfusion is not associated with an increase in amyloid β pathology in middle-aged or elderly people.

ABSTRACT:

Introduction

It is hypothesized that cerebral hypoperfusion promotes the development of Alzheimer pathology. We therefore studied whether longstanding cerebral hypoperfusion is associated with Alzheimer pathology in nondemented humans.

Methods

Cerebral blood flow and amyloid β (¹⁸F-Flutemetamol) positron emission tomography retention were assessed in eleven patients with unilateral occlusion of precerebral arteries resulting in chronic and uneven hypoperfusion. A subset of patients underwent tau (¹⁸F-AV-1451) positron emission tomography.

Results

The blood flow was significantly reduced on the affected side of the brain in patients with unilateral occlusion of the internal carotid artery or stenosis of the middle cerebral artery. However, the cor

SUBMITTER: Hansson O 

PROVIDER: S-EPMC5766833 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature