Peripheral blood gene expression signatures which reflect smoking and aspirin exposure are associated with cardiovascular events.

ABSTRACT:

Background

Cardiovascular disease and its sequelae are major causes of global mortality, and better methods are needed to identify patients at risk for future cardiovascular events. Gene expression analysis can inform on the molecular underpinnings of risk factors for cardiovascular events. Smoking and aspirin have known opposing effects on platelet reactivity and MACE, however their effects on each other and on MACE are not well described.

Methods

We measured peripheral blood gene expression levels of ITGA2B, which is upregulated by aspirin and correlates with platelet reactivity on aspirin, and a 5 gene validated smoking gene expression score (sGES) where higher expression correlates with smoking status, in participants from the previously reported PREDICT trial (NCT 00500

SUBMITTER: Wingrove JA 

PROVIDER: S-EPMC5767057 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature