Myopia in Chinese families shows linkage to 10q26.13.

ABSTRACT:

Purpose

To determine genetic linkage between myopia and Han Chinese patients with a family history of the disease.

Methods

One hundred seventy-six Han Chinese patients from 34 extended families were given eye examinations, and mean spherical equivalent (MSE) in diopters (D) was calculated by adding the spherical component of the refraction to one-half the cylindrical component and taking the average of both eyes. The MSE was converted to a binary phenotype, where all patients with an MSE of -1.00 D or less were coded as affected. Unaffected individuals had an MSE greater than 0.00 D (ages 21 years and up), +1.50 (ages 11-20), or +2.00 D (ages 6-10 years). Individuals between the given upper threshold and -1.00 were coded as unknown. Patients were genotyped on an exome chip.

SUBMITTER: Musolf AM 

PROVIDER: S-EPMC5767476 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature