Blocking LPA-dependent signaling increases ovarian cancer cell death in response to chemotherapy.

ABSTRACT: The paradoxical role of reactive oxygen species in cell death versus cell survival establishes a delicate balance between chemotherapy efficacy and management of detrimental side effects. Normal proliferative signaling requires that cells remain inside a redox range that allows reversible protein oxidation to occur. Shifting the redox environment toward highly reducing or oxidizing states leads to cellular stress and cell death. Reactive oxygen species produced in response to Taxol and cisplatin treatment are necessary for effective cancer cell killing but the same ROS leads to damaging side effects in normal tissues. Combining antioxidants with chemotherapeutics to alleviate the unwanted side effects produces variable and often undesirable effects on cancer treatment. Here, we describe a

SUBMITTER: Rogers LC 

PROVIDER: S-EPMC5767563 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature