The Role of Adenosine Receptors in Psychostimulant Addiction.

ABSTRACT: Adenosine receptors (AR) are a family of G-protein coupled receptors, comprised of four members, named A₁, A_2A, A_2B, and A₃ receptors, found widely distributed in almost all human body tissues and organs. To date, they are known to participate in a large variety of physiopathological responses, which include vasodilation, pain, and inflammation. In particular, in the central nervous system (CNS), adenosine acts as a neuromodulator, exerting different functions depending on the type of AR and consequent cellular signaling involved. In terms of molecular pathways and second messengers involved, A₁ and A₃ receptors inhibit adenylyl cyclase (AC), through G_i/o proteins, while A_2A and A_2B receptors

SUBMITTER: Ballesteros-Yanez I 

PROVIDER: S-EPMC5767594 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature