Age-Modulated Associations between KIBRA, Brain Volume, and Verbal Memory among Healthy Older Adults.

ABSTRACT: The resource modulation hypothesis suggests that the influence of genes on cognitive functioning increases with age. The KIBRA single nucleotide polymorphism rs17070145, associated with episodic memory and working memory, has been suggested to follow such a pattern, but few studies have tested this assertion directly. The present study investigated the relationship between KIBRA alleles (T carriers vs. CC homozygotes), cognitive performance, and brain volumes in three groups of cognitively healthy adults-middle aged (ages 52-64, n = 38), young old (ages 65-72, n = 45), and older old (ages 73-92, n = 62)-who were carefully matched on potentially confounding variables including apolipoprotein ε4 status and hypertension. Consistent with our prediction, T car

SUBMITTER: Stickel A 

PROVIDER: S-EPMC5767716 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature