Auto-Tandem Catalysis: Pd^II -Catalysed Dehydrogenation/Oxidative Heck Reaction of Cyclopentane-1,3-diones.

ABSTRACT: A Pd^II catalyst system has been used to successfully catalyse two mechanistically distinct reactions in a one-pot procedure: dehydrogenation of 2,2-disubstituted cyclopentane-1,3-diones and the subsequent oxidative Heck coupling. This auto-tandem catalytic reaction is applicable to both batch and continuous flow processes, with the latter being the first example of a tandem aerobic dehydrogenation/oxidative Heck in flow. In addition, a telescoped reaction involving enantioselective desymmetrisation of the all-C quaternary centre was successfully achieved.

SUBMITTER: Lamb CJC 

PROVIDER: S-EPMC5767738 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature