A Large Panel of Drosophila simulans Reveals an Abundance of Common Variants.

ABSTRACT: The rapidly expanding availability of large NGS data sets provides an opportunity to investigate population genetics at an unprecedented scale. Drosophila simulans is the sister species of the model organism Drosophila melanogaster, and is often presumed to share similar demographic history. However, previous population genetic and ecological work suggests very different signatures of selection and demography. Here, we sequence a new panel of 170 inbred genotypes of a North American population of D. simulans, a valuable complement to the DGRP and other D. melanogaster panels. We find some unexpected signatures of demography, in the form of excess intermediate frequency polymorphisms. Simulations suggest that this is possibly due to a recent population contraction and selection. We examine

SUBMITTER: Signor SA 

PROVIDER: S-EPMC5767965 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature