Long non-coding RNA Lucat1 is a poor prognostic factor and demonstrates malignant biological behavior in clear cell renal cell carcinoma.

ABSTRACT:

Background

Many long intergenic noncoding RNAs (lincRNAs) are encoded in the human genome. However, their biological functions, molecular mechanisms and prognostic values associated with clear cell renal cell carcinoma (ccRCC) have yet to be elucidated.

Methods

We screened the lncRNAs' profile in ccRCC from The Cancer Genome Atlas (TCGA) database, and selected Lucat1 for further study. MTS, colony formation assay and transwell assay were performed to examine the effect of Lucat1 on proliferation and metastasis of ccRCC. The Chip and Rip assay was performed to verify that Lucat1 can bind to polycomb PRC2 complex and suppress p57 expression.

Results

In this study, we found that lncRNA Lucat1 expression was significantly up regulated in tumor tissues compared to matched

SUBMITTER: Xiao H 

PROVIDER: S-EPMC5768351 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature