CD44 drives aggressiveness and chemoresistance of a metastatic human osteosarcoma xenograft model.

ABSTRACT:

Background

Osteosarcoma is the most common primary malignant bone tumor with a 5 year survival rate of up to 70%. However, patients with metastatic disease have still a very poor prognosis. Osteosarcoma metastasis models are essential to develop novel treatment strategies for advanced disease.

Methods

Based on a serial transplantation approach, we have established a U-2 OS osteosarcoma xenograft model with increased metastatic potential and compared it to other metastatic osteosarcoma models from international sources. Subclones with differing invasive potential were compared for genomic gains and losses as well as gene expression changes by several bioinformatic approaches. Based on the acquired results, the effects of a shRNA-mediated CD44 mRNA knockdown on migratio

SUBMITTER: Mayr L 

PROVIDER: S-EPMC5768389 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature