Association of miR-196a2 rs11614913 and miR-499 rs3746444 polymorphisms with cancer risk: a meta-analysis.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small non-coding RNA molecules, which participate in diverse biological processes and may regulate tumor suppressor genes or oncogenes. Rs11614913 in miR-196a2 and rs3746444 in miR-499 are shown to associate with increased/decreased cancer risk. This meta-analysis was performed to systematically assess the overall association.

Materials and methods

We searched Pubmed, Web of Knowledge, EMBASE, Chinese National Knowledge Infrastructure (CNKI) databases until December 2016 to identify eligible studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of the associations.

Results

We assessed published studies of the association between these microRNA polymorphisms and cancer risk from 56 studies wit

SUBMITTER: Yan W 

PROVIDER: S-EPMC5768408 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature