Genetic Heterogeneity in Therapy-Naive Synchronous Primary Breast Cancers and Their Metastases.

ABSTRACT: Purpose: Paired primary breast cancers and metachronous metastases after adjuvant treatment are reported to differ in their clonal composition and genetic alterations, but it is unclear whether these differences stem from the selective pressures of the metastatic process, the systemic therapies, or both. We sought to define the repertoire of genetic alterations in breast cancer patients with de novo metastatic disease who had not received local or systemic therapy.Experimental Design: Up to two anatomically distinct core biopsies of primary breast cancers and synchronous distant metastases from nine patients who presented with metastatic disease were subjected to high-depth whole-exome sequencing. Mutations, copy number alterations and their cancer cell fractions, and

SUBMITTER: Ng CKY 

PROVIDER: S-EPMC5768571 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature