A Study on Catalase Gene Promoter Polymorphism -21 A/T (rs7943316) in Healthy Pakistani population.

ABSTRACT:

Background & objective

Catalase (CAT) is an important endogenous antioxidant enzyme that detoxifies H₂O₂ into water and oxygen, consequently limiting the deleterious effects of reactive oxygen species. It has suggested that CAT-21A/T (rs7943316) OMIM: 115500 gene promoter polymorphism is predominantly associated with different human disorders such as hypertension, cancers, diabetes, nephropathy, and other diseases accompanied by oxidative stress. This study was designed to investigate the prevalence of mutant T allele frequency in healthy individuals.

Methods

The study group consisted of 110 healthy individuals were enrolled from Baqai Institute of Diabetology and Endocrinology (BIDE), Karachi, Pakistan, during the period of April 2010 to

SUBMITTER: Nawab SN 

PROVIDER: S-EPMC5768856 | biostudies-literature | 2017 Nov-Dec

REPOSITORIES: biostudies-literature