Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) significantly associated with chronic obstructive pulmonary disease (COPD). However, many genetic variants show suggestive evidence for association but do not meet the strict threshold for genome-wide significance. Integrative analysis of multiple omics datasets has the potential to identify novel genes involved in disease pathogenesis by leveraging these variants in a functional, regulatory context.

Results

We performed expression quantitative trait locus (eQTL) analysis using genome-wide SNP genotyping and gene expression profiling of lung tissue samples from 86 COPD cases and 31 controls, testing for SNPs associated with gene expression levels. These results were integ

SUBMITTER: Morrow JD 

PROVIDER: S-EPMC5769240 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature