Stress-inducible Protein-1 promotes metastasis of gastric cancer via Wnt/β-catenin signaling pathway.

ABSTRACT:

Background

Stress-Inducible Protein-1 (STIP1) is a co-chaperone that associates directly with heat shock proteins, and regulates motility of various types of cancer. In the present study, we investigated the role of STIP1 on metastasis of gastric cancer (GC).

Methods

In vivo metastatic experimental model was employed to investigate the effect of STIP1 on metastasis of GC cells. Loss-of-function and gain-of-function experiments were performed to examine the role of STIP1 on metastasis of GC cells. Western blot, immunofluorescence staining, migration and invasion assays, microarray and KEGG pathway analysis were applied to explore the underlying mechanism.

Results

In current study, we demonstrated that STIP1 promoted lung metastasis of GC cells in vivo. Furthermore, STI

SUBMITTER: Huang L 

PROVIDER: S-EPMC5769340 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature