Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics.

ABSTRACT: Purpose:To model the sensitivity of the optic nerve head (ONH) biomechanical environment to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery blood pressure (BP). Methods:We extended a previously published numerical model of the ONH to include 24 factors representing tissue anatomy and mechanical properties, all three pressures, and constraints on the optic nerve (CON). A total of 8340 models were studied to predict factor influences on 98 responses in a two-step process: a fractional factorial screening analysis to identify the 16 most influential factors, followed by a response surface methodology to predict factor effects in detail. Results:The six most influential factors were, in order: IOP, CON, moduli of the sclera, lamina cribrosa (LC) and dur

SUBMITTER: Hua Y 

PROVIDER: S-EPMC5769499 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature