ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells.

ABSTRACT:

Purpose

Uveal melanoma (UM) is uniformly refractory to all available systemic chemotherapies, thus creating an urgent need for novel therapeutics. In this study, we investigated the sensitivity of UM cells to ICG-001, a small molecule reported to suppress the Wnt/β-catenin-mediated transcriptional program.

Methods

We used a panel of UM cell lines to examine the effects of ICG-001 on cellular proliferation, migration, and gene expression. In vivo efficacy of ICG-001 was evaluated in a UM xenograft model.

Results

ICG-001 exerted strong antiproliferative activity against UM cells, leading to cell cycle arrest, apoptosis, and inhibition of migration. Global gene expression profiling revealed strong suppression of genes associated with cell cycle proliferation, DNA replica

SUBMITTER: Kaochar S 

PROVIDER: S-EPMC5769500 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature