Cost-effectiveness study of early versus late parenteral nutrition in critically ill children (PEPaNIC): preplanned secondary analysis of a multicentre randomised controlled trial.

ABSTRACT:

Background

The multicentre randomised controlled PEPaNIC trial showed that withholding parenteral nutrition (PN) during the first week of critical illness in children was clinically superior to providing early PN. This study describes the cost-effectiveness of this new nutritional strategy.

Methods

Direct medical costs were calculated with use of a micro-costing approach. We compared the costs of late versus early initiation of PN (n = 673 versus n = 670 patients) in the Belgian and Dutch study populations from a hospital perspective, using Student's t test with bootstrapping. Main cost drivers were identified and the impact of new infections on the total costs was assessed.

Results

Mean direct medical costs for patients receiving late PN (€26.680, IQR €10.090-28.830

SUBMITTER: van Puffelen E 

PROVIDER: S-EPMC5769527 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature