Postsurgical prescriptions for opioid naive patients and association with overdose and misuse: retrospective cohort study.

ABSTRACT: OBJECTIVE:To quantify the effects of varying opioid prescribing patterns after surgery on dependence, overdose, or abuse in an opioid naive population. DESIGN:Retrospective cohort study. SETTING:Surgical claims from a linked medical and pharmacy administrative database of 37 651 619 commercially insured patients between 2008 and 2016. PARTICIPANTS:1 015 116 opioid naive patients undergoing surgery. MAIN OUTCOME MEASURES:Use of oral opioids after discharge as defined by refills and total dosage and duration of use. The primary outcome was a composite of misuse identified by a diagnostic code for opioid dependence, abuse, or overdose. RESULTS:568 612 (56.0%) patients received postoperative opioids, and a code for abuse was identified for 5906 patients (0.6%, 183 per 100 000 person years). To

SUBMITTER: Brat GA 

PROVIDER: S-EPMC5769574 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature