<i>Lyplal1</i> is dispensable for normal fat deposition in mice.

ABSTRACT: Genome-wide association studies (GWAS) have detected association between variants in or near the Lysophospholipase-like 1 (LYPLAL1) locus and metabolic traits, including central obesity, fatty liver and waist-to-hip ratio. LYPLAL1 is also known to be upregulated in the adipose tissue of obese patients. However, the physiological role of LYPLAL1 is not understood. To investigate the function of Lyplal1 in vivo we investigated the phenotype of the Lyplal1^{tm1a(KOMP)Wtsi} homozygous mouse. Body composition was unaltered in Lyplal1 knockout mice as assessed by dual-energy X-ray absorptiometry (DEXA) scanning, both on normal chow and on a high-fat diet. Adipose tissue distribution between visceral and subcutaneous fat depots was unaltere

SUBMITTER: Watson RA 

PROVIDER: S-EPMC5769613 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature