Frizzled-7 is required for <i>Xenopus</i> heart development.

ABSTRACT: Wnt signalling regulates cardiogenesis during specification of heart tissue and the morphogenetic movements necessary to form the linear heart. Wnt11-mediated non-canonical signalling promotes early cardiac development whilst Wnt11-R, which is expressed later, also signals through the non-canonical pathway to promote heart development. It is unclear which Frizzled proteins mediate these interactions. Frizzled-7 (fzd7) is expressed during gastrulation in the mesodermal cells fated to become heart, and then in the primary heart field. This expression is complementary to the expression of wnt11 and wnt11-R We further show co-localisation of fzd7 with other early- and late-heart-specific markers using double in situ hybridisation. We have used loss of functio

SUBMITTER: Abu-Elmagd M 

PROVIDER: S-EPMC5769647 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature