Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations.

ABSTRACT: Although certain risk factors can identify individuals who are most likely to develop chronic pain, few interventions to prevent chronic pain have been identified. To facilitate the identification of preventive interventions, an IMMPACT meeting was convened to discuss research design considerations for clinical trials investigating the prevention of chronic pain. We present general design considerations for prevention trials in populations that are at relatively high risk for developing chronic pain. Specific design considerations included subject identification, timing and duration of treatment, outcomes, timing of assessment, and adjusting for risk factors in the analyses. We provide a detailed examination of 4 models of chronic pain prevention (ie, chronic postsurgical pain, postherpeti

SUBMITTER: Gewandter JS 

PROVIDER: S-EPMC5769693 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature