Novel Genetic Variants Associated with Lumbar Spondylosis in Koreans : A Genome-Wide Association Study.

ABSTRACT:

Objective

The aim of this study was to identify the susceptibility genes responsible for lumbar spondylosis (LS) in Korean patients.

Methods

Data from 1427 subjects were made available for radiographic grading and genome wide association studies (GWAS) analysis. Lateral lumbar spine radiographs were obtained and the various degrees of degenerative change were semi-quantitatively scored. A pilot GWAS was performed using the AffymetrixGenome-Wide Human single-nucleotide polymorphisms (SNPs), 500K array. A total of 352228 SNPs were analyzed and the association between the SNPs and case-control status was analyzed by stepwise logistic regression analyses.

Results

The top 100 SNPs with a cutoff p-value of less than 3.7×10^-4 were selected for joint space n

SUBMITTER: Kim HA 

PROVIDER: S-EPMC5769851 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature