Ontology highlight
ABSTRACT:
SUBMITTER: Costa-Silva B
PROVIDER: S-EPMC5769922 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Nature cell biology 20150518 6
Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular communication is critical for metastatic progression. Here, we show that PDAC-derived exosomes induce liver pre-metastatic niche formation in naive mice and consequently increase liver metastatic burden. Uptake of PDAC-derived exosomes by Kupffer cells caused transforming growth factor β secretion and upregulation of fibronectin production by he ...[more]