Factors influencing platelet clumping during peripheral blood hematopoietic stem cell collection.

ABSTRACT:

Background

Platelet clumping is a common occurrence during peripheral blood hematopoietic stem cell (HSC) collection using the Spectra Optia mononuclear cell (MNC) protocol. If clumping persists, it may prevent continuation of the collection and interfere with proper MNC separation. This study is the first to report the incidence of clumping, identify precollection factors associated with platelet clumping, and describe the degree to which platelet clumping interferes with HSC product yield.

Study design and methods

In total, 258 HSC collections performed on 116 patients using the Optia MNC protocol were reviewed. Collections utilized heparin in anticoagulant citrate dextrose to facilitate large-volume leukapheresis. Linear and logistic regression models were utilized to det

SUBMITTER: Mathur G 

PROVIDER: S-EPMC5769924 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature