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Proteoform Suite: Software for Constructing, Quantifying, and Visualizing Proteoform Families.

ABSTRACT: We present an open-source, interactive program named Proteoform Suite that uses proteoform mass and intensity measurements from complex biological samples to identify and quantify proteoforms. It constructs families of proteoforms derived from the same gene, assesses proteoform function using gene ontology (GO) analysis, and enables visualization of quantified proteoform families and their changes. It is applied here to reveal systemic proteoform variations in the yeast response to salt stress.

SUBMITTER: Cesnik AJ 

PROVIDER: S-EPMC5770237 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Proteoform Suite: Software for Constructing, Quantifying, and Visualizing Proteoform Families.

Cesnik Anthony J AJ   Shortreed Michael R MR   Schaffer Leah V LV   Knoener Rachel A RA   Frey Brian L BL   Scalf Mark M   Solntsev Stefan K SK   Dai Yunxiang Y   Gasch Audrey P AP   Smith Lloyd M LM  

Journal of proteome research 20171215 1

We present an open-source, interactive program named Proteoform Suite that uses proteoform mass and intensity measurements from complex biological samples to identify and quantify proteoforms. It constructs families of proteoforms derived from the same gene, assesses proteoform function using gene ontology (GO) analysis, and enables visualization of quantified proteoform families and their changes. It is applied here to reveal systemic proteoform variations in the yeast response to salt stress. ...[more]

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