Leucocyte cytokines dominate platelet cytokines overtime in non-leucoreduced platelet components.

ABSTRACT:

Background

Leucoreduction of blood components, including platelet components, is strongly encouraged but not yet universal, especially outside high income countries. As both leucocytes and platelets secrete copious amounts of pro-inflammatory cytokines/chemokines under various conditions and during storage, we investigated the potential of the respective secretory programmes of these cells in order to evaluate their subsequent pathophysiological effects.

Material and methods

A total of 158 individual non-leucoreduced platelet components were obtained from Tunisian donors and tested for characteristic biological response modifiers (BRM) of leukocytes (IL-1β, IL-8), platelets (sCD62P, sCD40L) and both cell types (TNF-α, RANTES) in the presence or absence of thrombin stimulatio

SUBMITTER: Aloui C 

PROVIDER: S-EPMC5770316 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature